Prognostic value of soluble ST2 in AL and TTR cardiac amyloidosis: a multicenter study
نویسندگان
چکیده
Background Both light-chain (AL) amyloidosis and transthyretin (ATTR) are types of cardiac (CA) that require accurate prognostic stratification to plan therapeutic strategies follow-ups. Cardiac biomarkers, e.g., N-terminal pro-B-type natriuretic peptide (NT-proBNP) high-sensitivity troponin T (Hs-cTnT), remain the cornerstone assessment. An increased level soluble suppression tumorigenesis-2 (sST2) is predictive adverse events [all-cause death heart failure (HF) hospitalizations] in patients with HF. This study aimed evaluate value circulating sST2 levels AL-CA ATTR-CA. Methods We carried out a multicenter including 133 152 During an elective outpatient visit for diagnosis CA, Mayo Clinic staging [NT-proBNP, Hs-cTnT, differential free light chains (DFLCs)] were assessed all AL patients. Gillmore [including estimated glomerular filtration rate (eGFR), NT-proBNP] Grogan (including NT-proBNP Hs-cTnT) TTR-CA Results The median age was 73 years [interquartile range (IQR) 61–81], 53% men. endpoint composite all-cause or first HF-related hospitalization. follow-up 20 months (IQR 3–34) 33 (6–45) TTR amyloidosis. primary outcome occurred 70 (53%) 99 (65%) patients, respectively. higher than ATTR-CA: 39 ng/L (26–80) vs. 32 (21–46), p < 0.001. In AL-CA, predicted regardless score (HR: 2.16, 95% CI: 1.17–3.99, 0.001). TTR-CA, not multivariate models, 1.17, 0.77–1.89, = 0.55). Conclusion relevant predictor HF hospitalization adds on top NT-proBNP, Hs cTnT, DFLC.
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2023
ISSN: ['2297-055X']
DOI: https://doi.org/10.3389/fcvm.2023.1179968